Purifying Selection Maintains Highly Conserved Noncoding Sequences in Drosophila -- Casillas et al. 24 (10): 2222 -- Molecular Biology and Evolution: "We find that point mutations in intronic and intergenic CNSs exhibit a significant reduction in levels of divergence relative to levels of polymorphism, as well as a significant excess of rare derived alleles, compared with either the nonconserved spacer regions between CNSs or with 4-fold silent sites in coding regions"
TOADD: more about the methods.
//Long time, no reading~
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