In this issue of
Cell, two studies from Jiang et al. (pp. 773–784) and Potok et al. (pp. 759–772) generate genome-wide methylome maps of zebrafish gametes and early embryos. Surprisingly, the sperm methylome remains largely unchanged until zygotic genome activation, and the oocyte undergoes a series of methylation-demethylation reprogramming cycles to ultimately match the patterns of sperm.
Question: How the piRNA dynamics co-incide with the methylation dynamics during MZT?
- Reprogramming the Maternal Zebrafish Genome after Fertilization to Match the Paternal Methylation Pattern p759
Magdalena E. Potok, David A. Nix, Timothy J. Parnell, Bradley R. Cairns
- Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos p773
Lan Jiang, Jing Zhang, Jing-Jing Wang, Lu Wang, Li Zhang, Guoqiang Li, Xiaodan Yang, Xin Ma, Xin Sun, Jun Cai, Jun Zhang, Xingxu Huang, Miao Yu, Xuegeng Wang, Feng Liu, Chung-I Wu, Chuan He, Bo Zhang, Weimin Ci, Jiang Liu
