Conservation of transcription factor binding events predicts gene expression across species

Conservation of transcription factor binding events predicts gene expression across species: "We show that (i) there is a significantly higher degree of conservation of TFBEs when the target gene is expressed in both species; (ii) there is increased conservation of binding events for groups of TFs compared to individual TFs; and (iii) conserved TFBEs have a greater impact on the expression of their target genes than non-conserved ones. These results link conservation of structural elements (TFBEs) to conservation of function (gene expression) and suggest a higher degree of functional conservation than implied by previous studies."

Interesting point!

It's also worthy to check the cross-cellline cases.