Wednesday, May 22, 2013

DNA methylome changes along the maternal-to-zygotic transition

In this issue of Cell, two studies from Jiang et al. (pp. 773–784) and Potok et al. (pp. 759–772) generate genome-wide methylome maps of zebrafish gametes and early embryos. Surprisingly, the sperm methylome remains largely unchanged until zygotic genome activation, and the oocyte undergoes a series of methylation-demethylation reprogramming cycles to ultimately match the patterns of sperm.

Question: How the piRNA dynamics co-incide with the methylation dynamics during MZT?

Reprogramming the Maternal Zebrafish Genome after Fertilization to Match the Paternal Methylation Pattern p759
Magdalena E. Potok, David A. Nix, Timothy J. Parnell, Bradley R. Cairns
In Brief | Summary | Full Text
Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos p773
Lan Jiang, Jing Zhang, Jing-Jing Wang, Lu Wang, Li Zhang, Guoqiang Li, Xiaodan Yang, Xin Ma, Xin Sun, Jun Cai, Jun Zhang, Xingxu Huang, Miao Yu, Xuegeng Wang, Feng Liu, Chung-I Wu, Chuan He, Bo Zhang, Weimin Ci, Jiang Liu
In Brief | Summary | Full Text

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